Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 317)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2034048	0.0998187	0.0543708
Weighted median	23	0.1224078	0.0581231	0.0352034
Inverse variance weighted	23	0.1022808	0.0390150	0.0087525
Simple mode	23	0.0509408	0.0881966	0.5694108
Weighted mode	23	0.1704833	0.0715803	0.0263093

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.53870	21	0.5506245
Inverse variance weighted	20.75009	22	0.5362255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062101	0.0056423	0.2835141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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