Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 316)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0243538	0.1060995	0.8206719
Weighted median	23	-0.0460920	0.0566497	0.4158555
Inverse variance weighted	23	-0.0238726	0.0407513	0.5580019
Simple mode	23	-0.0484090	0.1006705	0.6353597
Weighted mode	23	-0.0394059	0.0716931	0.5880986

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.72567	21	0.3065397
Inverse variance weighted	24.00118	22	0.3471676

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029616	0.0059973	0.6265563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007386	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8