Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 315)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0394381	0.0998200	0.6967598
Weighted median	23	-0.0737322	0.0534229	0.1675369
Inverse variance weighted	23	-0.0616890	0.0390156	0.1138473
Simple mode	23	-0.0204040	0.0893103	0.8213975
Weighted mode	23	-0.0640068	0.0617543	0.3112396

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.81906	21	0.6604243
Inverse variance weighted	17.87771	22	0.7132141

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013664	0.0056423	0.8109935

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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