Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 314)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1957635	0.0998194	0.0632535
Weighted median	23	0.0528621	0.0548303	0.3349932
Inverse variance weighted	23	0.0317384	0.0394314	0.4208764
Simple mode	23	0.0648068	0.0912135	0.4848613
Weighted mode	23	0.0730333	0.0626792	0.2564200

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.28466	21	0.5668852
Inverse variance weighted	22.47172	22	0.4320530

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0100728	0.0056423	0.088676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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