Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 313)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1292986	0.0998199	0.2092696
Weighted median	23	0.0306333	0.0557301	0.5825438
Inverse variance weighted	23	0.0330144	0.0390154	0.3974481
Simple mode	23	-0.0363475	0.1011015	0.7226379
Weighted mode	23	0.0336282	0.0729079	0.6491520

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.27128	21	0.8090978
Inverse variance weighted	16.36946	22	0.7971358

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059128	0.0056423	0.3065774

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005177	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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