Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 312)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0044547	0.1036248	0.9661165
Weighted median	23	0.0199595	0.0545833	0.7146111
Inverse variance weighted	23	0.0091948	0.0395739	0.8162701
Simple mode	23	0.0358954	0.0900557	0.6940367
Weighted mode	23	0.0157051	0.0629119	0.8051843

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63124	21	0.3639506
Inverse variance weighted	22.63390	22	0.4226422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002911	0.0058573	0.9608343

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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