Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 311)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1047665	0.1004329	0.3087400
Weighted median	23	-0.0437654	0.0578110	0.4490245
Inverse variance weighted	23	-0.0448350	0.0406737	0.2703273
Simple mode	23	-0.0066581	0.1231519	0.9573722
Weighted mode	23	0.0983656	0.1006512	0.3390494

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.25881	21	0.4432389
Inverse variance weighted	23.90998	22	0.3519657

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009187	0.005677	0.1205205

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007646	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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