Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 310)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1228938	0.1153836	0.2989293
Weighted median	23	-0.0964111	0.0606913	0.1121625
Inverse variance weighted	23	-0.0705219	0.0443162	0.1115347
Simple mode	23	-0.0852257	0.0982064	0.3948597
Weighted mode	23	-0.0918788	0.0650478	0.1717986

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.05961	21	0.1384687
Inverse variance weighted	28.38453	22	0.1632851

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032162	0.006522	0.6270439

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009591	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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