Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 31)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0811766	0.0998201	0.4252118
Weighted median	23	-0.1028873	0.0580964	0.0765647
Inverse variance weighted	23	-0.0385952	0.0390154	0.3225502
Simple mode	23	-0.0810634	0.1018778	0.4347126
Weighted mode	23	-0.1002318	0.0734543	0.1861914

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.19059	21	0.5729154
Inverse variance weighted	19.40537	22	0.6201812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026149	0.0056423	0.6478113

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006177	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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