Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 309)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1084724	0.1204315	0.3779629
Weighted median	23	0.0566137	0.0556086	0.3086426
Inverse variance weighted	23	0.0500025	0.0462926	0.2800793
Simple mode	23	0.1124015	0.0953723	0.2511660
Weighted mode	23	0.0874813	0.0635245	0.1823249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.56763	21	0.0811610
Inverse variance weighted	30.97260	22	0.0966776

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035906	0.0068074	0.6034022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009883	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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