Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 308)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0208672	0.0998203	0.8364254
Weighted median	23	-0.0196781	0.0583254	0.7358266
Inverse variance weighted	23	0.0114780	0.0390155	0.7686126
Simple mode	23	0.0057934	0.1052657	0.9566063
Weighted mode	23	-0.0416613	0.0779018	0.5981582

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.30206	21	0.5657703
Inverse variance weighted	19.42599	22	0.6188972

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019863	0.0056423	0.7283174

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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