Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 307)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0065543	0.0998207	0.9482693
Weighted median	23	0.0381451	0.0566646	0.5008377
Inverse variance weighted	23	-0.0021683	0.0390157	0.9556811
Simple mode	23	0.1008390	0.1021478	0.3342845
Weighted mode	23	0.0498044	0.0714732	0.4932098

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.34592	21	0.6899355
Inverse variance weighted	17.34820	22	0.7438585

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002693	0.0056423	0.9623776

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005258	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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