Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 306)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1241661	0.0998211	0.2272478
Weighted median	23	-0.0501106	0.0570255	0.3795422
Inverse variance weighted	23	-0.0450105	0.0390158	0.2486444
Simple mode	23	-0.0235115	0.0940917	0.8050001
Weighted mode	23	-0.0171110	0.0674730	0.8021616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.31024	21	0.8070691
Inverse variance weighted	18.70051	22	0.6637420

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0103891	0.0056424	0.0797539

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000607	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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