Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 305)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0186976	0.0998208	0.8532141
Weighted median	23	0.0295660	0.0601248	0.6229007
Inverse variance weighted	23	-0.0008739	0.0390155	0.9821291
Simple mode	23	0.0888929	0.1079505	0.4190842
Weighted mode	23	0.0574328	0.0666640	0.3982417

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.22364	21	0.6348112
Inverse variance weighted	18.26901	22	0.6899248

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012019	0.0056424	0.8333722

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005536	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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