Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 304)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0184188	0.0998204	0.8553759
Weighted median	23	0.0942995	0.0547118	0.0847859
Inverse variance weighted	23	0.0507971	0.0390154	0.1929254
Simple mode	23	0.0963247	0.0914443	0.3036039
Weighted mode	23	0.0902231	0.0629864	0.1660799

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.88416	21	0.5925713
Inverse variance weighted	19.00834	22	0.6448134

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019883	0.0056423	0.7280522

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006274	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8