Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 303)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0693403	0.0998209	0.4948906
Weighted median	23	0.0248449	0.0536519	0.6433103
Inverse variance weighted	23	0.0091174	0.0390158	0.8152299
Simple mode	23	0.0031593	0.0823967	0.9697608
Weighted mode	23	0.0194868	0.0612469	0.7533587

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.70147	21	0.9473285
Inverse variance weighted	12.13109	22	0.9546124

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036983	0.0056424	0.5192942

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003693	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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