Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 302)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0991916	0.0998202	0.3316802
Weighted median	23	0.0712377	0.0569095	0.2106533
Inverse variance weighted	23	0.0672559	0.0390155	0.0847392
Simple mode	23	0.0176634	0.1042068	0.8669498
Weighted mode	23	0.0753608	0.0655520	0.2626391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.53228	21	0.4878058
Inverse variance weighted	20.65310	22	0.5422565

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019612	0.0056423	0.731613

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007159	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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