Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 301)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0701862	0.0998210	0.4897033
Weighted median	23	0.0315743	0.0552271	0.5675136
Inverse variance weighted	23	0.0307918	0.0390160	0.4299893
Simple mode	23	0.0393049	0.0847689	0.6474383
Weighted mode	23	0.0437572	0.0632168	0.4960678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.77189	21	0.8791967
Inverse variance weighted	13.95572	22	0.9030433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024192	0.0056424	0.6724657

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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