Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 300)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0621257	0.0998198	0.5403928
Weighted median	23	0.0916317	0.0550771	0.0961729
Inverse variance weighted	23	0.0294837	0.0390155	0.4498337
Simple mode	23	-0.1335456	0.1001336	0.1959552
Weighted mode	23	0.0913934	0.0613552	0.1505322

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.11694	21	0.5776387
Inverse variance weighted	19.24316	22	0.6302692

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020045	0.0056423	0.7259305

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006004	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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