Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 30)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0494499	0.0998212	0.6254726
Weighted median	23	0.0422447	0.0554624	0.4462498
Inverse variance weighted	23	0.0054471	0.0390158	0.8889668
Simple mode	23	0.0541102	0.0847116	0.5295754
Weighted mode	23	0.0628237	0.0669005	0.3578962

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.11893	21	0.9363514
Inverse variance weighted	12.34829	22	0.9497631

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027022	0.0056424	0.6369492

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003748	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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