Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 3)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0597998	0.0998205	0.5555321
Weighted median	23	-0.0135972	0.0549999	0.8047361
Inverse variance weighted	23	0.0043011	0.0390158	0.9122186
Simple mode	23	0.0145214	0.0900885	0.8734142
Weighted mode	23	-0.0342863	0.0614213	0.5823344

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.68988	21	0.9190974
Inverse variance weighted	13.05474	22	0.9316233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034082	0.0056424	0.5522899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000396	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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