Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 299)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1663671	0.0998205	0.1104283
Weighted median	23	0.0408045	0.0577430	0.4797800
Inverse variance weighted	23	-0.0136864	0.0390156	0.7257431
Simple mode	23	0.0176502	0.1031632	0.8657171
Weighted mode	23	0.0532981	0.0656923	0.4258672

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.94158	21	0.7146412
Inverse variance weighted	20.78186	22	0.5342525

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.011057	0.0056423	0.0634417

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006335	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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