Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 298)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0272442	0.1030260	0.7940191
Weighted median	23	0.0242067	0.0539266	0.6535162
Inverse variance weighted	23	0.0246427	0.0396219	0.5339778
Simple mode	23	0.0504924	0.0884741	0.5739848
Weighted mode	23	0.0321415	0.0663956	0.6331053

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.37019	21	0.3784533
Inverse variance weighted	22.68910	22	0.4194591

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031864	0.0058235	0.590041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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