Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 297)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1085302	0.1070811	0.3223416
Weighted median	23	0.0135570	0.0556037	0.8073748
Inverse variance weighted	23	0.0598112	0.0436390	0.1705032
Simple mode	23	-0.0005496	0.0771958	0.9943833
Weighted mode	23	0.0065181	0.0573019	0.9104670

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.16617	21	0.2850771
Inverse variance weighted	27.52311	22	0.1920286

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0103377	0.0060527	0.1023861

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009051	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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