Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 296)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0781325	0.1004322	0.4452680
Weighted median	23	0.0431161	0.0536182	0.4213214
Inverse variance weighted	23	-0.0006805	0.0390155	0.9860849
Simple mode	23	-0.0293119	0.0944467	0.7592131
Weighted mode	23	0.0551633	0.0568551	0.3424719

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.25812	21	0.4432808
Inverse variance weighted	21.99391	22	0.4602525

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048399	0.0056769	0.4035237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006665	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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