Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 295)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0198448	0.0998199	0.8443266
Weighted median	23	0.0216466	0.0538467	0.6876813
Inverse variance weighted	23	0.0184678	0.0390156	0.6359674
Simple mode	23	0.0419617	0.0972319	0.6702590
Weighted mode	23	0.0138001	0.0768199	0.8590782

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.43219	21	0.8006579
Inverse variance weighted	15.43242	22	0.8430224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-8.46e-05	0.0056423	0.9881842

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004744	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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