Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 294)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0074573	0.1113618	0.9472431
Weighted median	23	-0.0131430	0.0547983	0.8104516
Inverse variance weighted	23	-0.0061094	0.0425258	0.8857659
Simple mode	23	-0.1107257	0.0930174	0.2465852
Weighted mode	23	-0.0179935	0.0650817	0.7847630

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.13652	21	0.2012912
Inverse variance weighted	26.13674	22	0.2458575

Test for directional horizontal pleiotropy

egger_intercept	se	pval
8.28e-05	0.0062947	0.9896323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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