Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 293)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0732564	0.1196174	0.5468334
Weighted median	23	0.0446384	0.0615528	0.4683262
Inverse variance weighted	23	0.0726067	0.0475489	0.1267633
Simple mode	23	0.2212311	0.1172376	0.0724219
Weighted mode	23	0.0536826	0.0742672	0.4773991

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.15635	21	0.0888910
Inverse variance weighted	32.67669	22	0.0665688

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0089574	0.0067613	0.199474

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010951	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8