Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 292)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1143481	0.1013715	0.2720389
Weighted median	23	-0.0349539	0.0542975	0.5197389
Inverse variance weighted	23	-0.0121466	0.0398015	0.7602285
Simple mode	23	-0.0355696	0.0896063	0.6952261
Weighted mode	23	-0.0416102	0.0608832	0.5014626

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.65773	21	0.4194583
Inverse variance weighted	22.89503	22	0.4076774

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062761	0.00573	0.2857805

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006967	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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