Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 291)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1060390	0.0998207	0.3001662
Weighted median	23	-0.0092634	0.0536513	0.8629198
Inverse variance weighted	23	-0.0176476	0.0390159	0.6510396
Simple mode	23	0.0539734	0.0851094	0.5325123
Weighted mode	23	-0.0021107	0.0580348	0.9713154

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.04718	21	0.5182743
Inverse variance weighted	20.97269	22	0.5224267

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054281	0.0056423	0.3469816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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