Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 290)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2704210	0.0998148	0.0131381
Weighted median	23	0.1469693	0.0635054	0.0206524
Inverse variance weighted	23	0.1377870	0.0390143	0.0004129
Simple mode	23	0.1622388	0.1181338	0.1834797
Weighted mode	23	0.1801298	0.0921332	0.0633928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.57647	21	0.7364379
Inverse variance weighted	18.66059	22	0.6661827

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081453	0.0056422	0.1635913

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009433	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8