Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 29)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0779127	0.1029920	0.4577572
Weighted median	23	-0.0811462	0.0522328	0.1202918
Inverse variance weighted	23	-0.0552161	0.0393837	0.1609141
Simple mode	23	-0.0809729	0.0976476	0.4158778
Weighted mode	23	-0.0866596	0.0665643	0.2064205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.35617	21	0.3792407
Inverse variance weighted	22.41719	22	0.4352363

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013938	0.0058216	0.8131022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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