Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 289)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1334654	0.1103953	0.2401081
Weighted median	23	0.0530066	0.0564825	0.3480085
Inverse variance weighted	23	0.0146920	0.0442390	0.7398091
Simple mode	23	0.0367648	0.1163856	0.7550647
Weighted mode	23	0.0200411	0.0759841	0.7944244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.68514	21	0.2187096
Inverse variance weighted	28.28534	22	0.1664164

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090983	0.0062401	0.1596215

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008614	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8