Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 288)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0052160	0.1277572	0.9678191
Weighted median	23	0.0407982	0.0556903	0.4638080
Inverse variance weighted	23	-0.0315835	0.0489006	0.5183632
Simple mode	23	0.0276681	0.1075828	0.7994306
Weighted mode	23	0.0228816	0.0617908	0.7146944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.39971	21	0.0328231
Inverse variance weighted	34.56013	22	0.0430431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022598	0.0072214	0.7574159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010671	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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