Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 287)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0765236	0.1302195	0.5630331
Weighted median	23	0.0778766	0.0592585	0.1887839
Inverse variance weighted	23	0.0130126	0.0503832	0.7961966
Simple mode	23	0.0735859	0.1095319	0.5086915
Weighted mode	23	0.0735859	0.0797269	0.3660333

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.73940	21	0.023385
Inverse variance weighted	36.68906	22	0.025582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054984	0.0073607	0.4633451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001115	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8