Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 286)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2190127	0.1377354	0.1267555
Weighted median	23	0.0234730	0.0634110	0.7112547
Inverse variance weighted	23	0.0238504	0.0554858	0.6673071
Simple mode	23	0.0819197	0.1248753	0.5186188
Weighted mode	23	0.0585764	0.0744829	0.4399983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.98442	21	0.0074693
Inverse variance weighted	44.49645	22	0.0030727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0119848	0.0077854	0.1386412

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013596	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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