Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 285)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0590146	0.1305524	0.6558766
Weighted median	23	-0.0842386	0.0619353	0.1737960
Inverse variance weighted	23	-0.0409825	0.0498810	0.4113014
Simple mode	23	-0.1034782	0.1020578	0.3216437
Weighted mode	23	-0.1194426	0.0803305	0.1512365

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.92268	21	0.0223065
Inverse variance weighted	35.96120	22	0.0306583

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011074	0.0073795	0.8821505

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011231	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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