Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 284)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0284917	0.0998209	0.7781127
Weighted median	23	0.0442568	0.0556612	0.4265498
Inverse variance weighted	23	0.0812927	0.0390157	0.0371974
Simple mode	23	0.0583817	0.0823211	0.4856522
Weighted mode	23	0.0486220	0.0605942	0.4308932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.20804	21	0.9011622
Inverse variance weighted	13.53829	22	0.9170534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032425	0.0056424	0.5716187

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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