Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 283)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2092157	0.0998197	0.0483836
Weighted median	23	-0.0926035	0.0538640	0.0855765
Inverse variance weighted	23	-0.0420288	0.0390155	0.2813760
Simple mode	23	-0.1067298	0.0861661	0.2285281
Weighted mode	23	-0.1142204	0.0655048	0.0951717

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.26469	21	0.9573809
Inverse variance weighted	14.57578	22	0.8797913

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.010267	0.0056423	0.0831006

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004769	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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