Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 282)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0259476	0.0998205	0.7974398
Weighted median	23	0.0156370	0.0545521	0.7743854
Inverse variance weighted	23	-0.0251985	0.0390156	0.5183723
Simple mode	23	-0.1375154	0.1083318	0.2175667
Weighted mode	23	0.0019385	0.0744992	0.9794759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.08449	21	0.7059719
Inverse variance weighted	17.08456	22	0.7586777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
4.6e-05	0.0056423	0.9935717

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005304	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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