Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 281)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1056770	0.1089594	0.3431477
Weighted median	23	0.0158491	0.0540082	0.7691730
Inverse variance weighted	23	0.0449279	0.0419704	0.2844094
Simple mode	23	-0.0605220	0.1042455	0.5674290
Weighted mode	23	0.0515649	0.0642681	0.4309384

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.02155	21	0.2462321
Inverse variance weighted	25.45871	22	0.2756457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037306	0.0061589	0.5511896

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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