Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 280)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1046021	0.0998204	0.3065949
Weighted median	23	-0.0814529	0.0519537	0.1169283
Inverse variance weighted	23	-0.0822230	0.0390156	0.0350795
Simple mode	23	-0.0709422	0.0800562	0.3851187
Weighted mode	23	-0.0761543	0.0615535	0.2290548

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.03592	21	0.9073606
Inverse variance weighted	13.09525	22	0.9304708

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013743	0.0056423	0.8099279

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005314	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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