Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 28)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1070256	0.1056201	0.3224469
Weighted median	23	0.0527479	0.0552015	0.3392985
Inverse variance weighted	23	0.0171532	0.0411455	0.6767573
Simple mode	23	0.0490809	0.0960340	0.6143875
Weighted mode	23	0.0828798	0.0598770	0.1801891

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.51109	21	0.3173449
Inverse variance weighted	24.46787	22	0.3231912

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055191	0.0059702	0.365759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007472	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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