Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 279)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1382461	0.0998200	0.1806046
Weighted median	23	-0.1098475	0.0530260	0.0383046
Inverse variance weighted	23	-0.0788975	0.0390153	0.0431537
Simple mode	23	0.0171096	0.0881079	0.8478096
Weighted mode	23	-0.0986814	0.0638769	0.1366426

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.98220	21	0.7706501
Inverse variance weighted	16.39944	22	0.7955790

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036446	0.0056423	0.5253148

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006208	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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