Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 278)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0085162	0.0998211	0.9328191
Weighted median	23	0.0026046	0.0553981	0.9624997
Inverse variance weighted	23	0.0243554	0.0390158	0.5324665
Simple mode	23	-0.0028952	0.0839271	0.9727926
Weighted mode	23	0.0019169	0.0622614	0.9757163

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.91711	21	0.8270881
Inverse variance weighted	14.94682	22	0.8645099

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009727	0.0056423	0.8647823

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004647	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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