Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 277)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0518973	0.1422803	0.7189427
Weighted median	23	0.0484277	0.0597673	0.4177843
Inverse variance weighted	23	0.0475169	0.0543346	0.3818326
Simple mode	23	0.0630622	0.1028101	0.5459117
Weighted mode	23	0.0521993	0.0903155	0.5691563

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.66668	21	0.003466
Inverse variance weighted	42.66895	22	0.005182

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000269	0.0080424	0.9736335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013378	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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