Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 276)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0419017	0.0998211	0.6789184
Weighted median	23	-0.0019992	0.0568293	0.9719367
Inverse variance weighted	23	-0.0056592	0.0390158	0.8846715
Simple mode	23	-0.0193068	0.0900316	0.8321758
Weighted mode	23	-0.0162812	0.0610965	0.7923489

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.63415	21	0.7330308
Inverse variance weighted	16.78974	22	0.7748572

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022256	0.0056424	0.6972245

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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