Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 275)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0585199	0.1242862	0.6426038
Weighted median	23	0.0661811	0.0576970	0.2513630
Inverse variance weighted	23	0.0310848	0.0475264	0.5130783
Simple mode	23	0.0855076	0.0992264	0.3981250
Weighted mode	23	0.0605073	0.0635036	0.3510349

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.55629	21	0.0513746
Inverse variance weighted	32.64545	22	0.0670384

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016848	0.0070252	0.8127962

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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