Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 274)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0416117	0.1327369	0.7570009
Weighted median	23	0.0055574	0.0594457	0.9255166
Inverse variance weighted	23	0.0788445	0.0518484	0.1283421
Simple mode	23	0.0847877	0.1093562	0.4463965
Weighted mode	23	-0.0111106	0.0609411	0.8570039

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.13433	21	0.0162461
Inverse variance weighted	38.85315	22	0.0146685

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073971	0.0075029	0.3354015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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