Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 273)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0185479	0.1063207	0.8631811
Weighted median	23	-0.0359593	0.0564351	0.5240078
Inverse variance weighted	23	-0.0109655	0.0406066	0.7871280
Simple mode	23	-0.0066427	0.0853759	0.9386864
Weighted mode	23	-0.0140072	0.0628301	0.8256406

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.82379	21	0.3016743
Inverse variance weighted	23.83060	22	0.3561711

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004656	0.0060097	0.9389755

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8